SOLUBILITY ENHANCEMENT OF IBUPROFEN AND ACETYL SALICYLIC ACID AFTER COMMINUTION

Article Sidebar

PDF
Published: 2025-08-27
Keywords:
Dilution, Solubility, Crystalline, Bioavailability

Main Article Content

Aisha Liaqat
Omer Mahmood Mumtaz
Anum Zaeem
Zunaira Tahir
Subat Mirza
Wali Ullah Shahid
Rabia Javaid

Abstract

The poor solubility of potential drug molecules is a significant problem in the design of pharmaceutical formulations. It is well known, however, that the solubility of crystalline materials is enhanced when the particle size is reduced to submicron levels and this factor can be expected to enhance drug product bioavailability. The aim of our study was to enhance to solubility of acetylsalicylic acid and ibuprofen by shake flask method and also by reducing particle size, for this purpose we make dilutions of stock solution and saturated solution and find their absorbance. Our data clearly shows that after shaking and particle size reduction, solubility of our studied class 2 drugs is increased.

Downloads

Download data is not yet available.

Article Details

Issue

Vol. 3 No. 8 (2025): The Research of Medical Science Review

Section

Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

SOLUBILITY ENHANCEMENT OF IBUPROFEN AND ACETYL SALICYLIC ACID AFTER COMMINUTION. (2025). The Research of Medical Science Review, 3(8), 1014-1027. https://medicalsciencereview.com/index.php/Journal/article/view/1971