EFFECT OF PLATELET RICH PLASMA AND STEROID INJECTION ON TINNITIS

Abstract

Objectives: Sensorineural hearing loss (SNHL) is a widespread auditory disorder caused by damage to the inner ear or auditory nerve pathways. Traditional treatments primarily manage symptoms rather than restore function. Platelet-Rich Plasma (PRP), a regenerative therapy, has shown potential in otologic applications. This study aimed to compare the efficacy and safety of intratympanic PRP injections versus steroid (dexamethasone) injections in patients with chronic tinnitus associated with SNHL. Methodology: This prospective, comparative clinical trial included 40 patients with subjective, non-pulsatile tinnitus lasting over three months. Participants were randomly assigned to two groups: Group A received intratympanic PRP injections, and Group B received intratympanic steroid injections. Treatments were administered weekly for three sessions. Tinnitus severity was assessed using the Tinnitus Handicap Inventory (THI) and Visual Analog Scale (VAS) for loudness and annoyance at baseline, 2 weeks, 1 month, and 3 months post-treatment. Audiometric evaluations monitored hearing thresholds. Data were analyzed using paired t-tests and ANOVA; p < 0.05 was considered statistically significant. Results: Both groups showed significant improvements in THI and VAS scores. However, the PRP group exhibited more substantial and sustained reductions, with significant differences appearing as early as two weeks post-treatment. By three months, PRP patients had over 50% improvement in VAS scores. No adverse effects or hearing deterioration were reported in either group. Conclusion:: Intratympanic PRP injections were more effective and longer-lasting than steroid therapy in reducing tinnitus symptoms and were found to be safe. PRP may offer a promising treatment option for chronic tinnitus.