EARLY GOAL DIRECTED THERAPY IN SEVERE SEPSIS AND SEPTIC SHOCK

Abstract

Hypothesis: The aim of the study will be to observe early goal directed therapy in severe sepsis and septic shock.

Design of the Study: Prospective, randomized, controlled clinical study

Study Duration: 06 months, October 2024 to February 2025

Location of Study: Department of Medicine, CMH Lahore

Methods: A total of 100 patients were randomly divided into EGDT and conventional therapy groups. Data on clinical parameters, outcomes, and mortality were analyzed using SPSS 26.0, with significance set at p<0.05 and survival assessed via Kaplan–Meier and Cox regression analyses.

Results: 100 patients with severe sepsis or septic shock were seen. The Early Goal-Directed Therapy (EGDT) led to faster hemodynamic stabilization, improved lactate clearance, and significantly lower 28-day mortality (26% vs. 42%, p=0.048) compared to conventional therapy. EGDT also shortened ICU stay without enhancing adverse events, demonstrating its safety and effectiveness in improving survival and organ function recovery in critically ill patients.

Conclusion: Early Goal-Directed Therapy (EGDT) improves hemodynamic stability, tissue perfusion, ICU stay, and short-term survival in severe sepsis and septic shock.