STUDIES ON THE EFFECTS OF CHRONIC LIVER DISEASE ON RENAL FUNCTIONS AT KHAIRPUR, SINDH

Abstract

Aims and objectives: In CLD patients Derangements in various homeostatic mechanisms leading to direct renal injury have been observed. Therefore present study was designed to observe the renal impairment in chronic liver patients.

Materials and methods: A comparative cross-sectional study was conducted at PAQSJIMS and Civil Hospital Khairpur during June 2024 to February 2025. A total of 167 CLD patients with 120 (71.9%) male and 47 (28.1%) female patients and 50 healthy subjects were assessed for renal functions. Serum creatinine, Blood urea nitrogen and electrolytes (Sodium, potassium, chlorides) were assessed for renal function. Automatic Analyzer machine Advia 1800 Siemens (Germany) was used to measure the renal markers. Demographic details, history of CLD, and relevant clinical findings were the part of data collection proforma.

Results: A total of 167 subjects out of which 43(35.8%) were HBsAg +ve males and 10(21.3%) were HBsAg +ve females and in HBsAg –ve cases 77 (64.2%) were males and 37(78.7%) were females. Among HCV +ve cases 57(47.5%) were males and 25 (53.1%) were females and among HCV -ve subjects 63(52.5%) were males and 22(46.9%) were females. Hepatitis B and Hepatitis C infected CLD groups show elevated creatinine approximately 1.8 mg/dl and co-morbid shows 1.6 mg/dL compared to normal. When BUN was observed in different CLD conditions, the Co-Morbid group demonstrated a significant elevation (p < 0.05) while there was no significant change in all other groups. In each CLD condition lower sodium and chloride level was observed likely indicating hyponatremia and hypochloremia respectively.

Conclusion: In CLD patients renal markers were significantly altered.