THERAPEUTIC ROLE OF PROBIOTICS IN ANTIBIOTIC INDUCED DIARRHEA

Abstract

Objective: To find the therapeutic role of probiotics in antibiotics induced diarrhea

Study Design: Prospective Observational Study

Place of Study: CMH Quetta

Patients and Methodology: 200 patients 100 (50%) were administered probiotics concurrently with antibiotics, while the remaining 100 (50%) did not receive probiotics were reported to tertiary care hospital were selected. Convenience sampling was performed.  The primary outcome measure was the incidence and severity of antibiotic-induced diarrhea among patients who received probiotics compared to those who did not. Secondary outcomes included the duration of diarrhea, time to resolution of symptoms, and any adverse events associated with probiotic use.

Results: Out of 278 patients, 110 (55%) were female and 90 (45%) were male. Our findings revealed a statistically significant difference in the incidence of AID between patients who received probiotics concurrently with antibiotics and those who did not. Among the group administered probiotics, 30% developed AID, whereas in the non-probiotic group, the incidence rose to 45%.

Conclusion: Statistically significant reduction in the incidence of AID among patients receiving probiotics concurrently with antibiotics compared to those who did not.