ASSESSMENT OF ANTIMICROBIAL AND ANTICANCER ACTIVITIES OF NOVEL TRANSITION METAL DERIVED COMPOUNDS

Abstract

Microorganisms are present everywhere in the biosphere and part of the human normal flora where it helps in the maintenance of the homeostasis. Along with these useful microorganisms some of these are harmful to the body and pathogenic in nature. These pathogenic microorganisms causes diseases in humans and other animals. Diseases caused by these pathogenic microorganisms are treated with a variety of antimicrobial agent both from natural and synthetic sources. Antimicrobial agents from synthetic sources are in common practice and prescribed by a clinician for the treatment of infectious diseases. However, today a majority of microorganism have shown resistance to these synthetic antimicrobial agents and it is time to discover new synthetic drugs to overcome the resistance issue; otherwise, it could become a global threat. Among these synthetic antimicrobial agents reported, studies on transitional metal compounds have shown activities against a large number of microorganisms.

Method: In the current study transitional metals derivatives were studied for the evaluation of antimicrobial potential and anticancer activity which shows that the tested transitional metal compounds has both antibacterial and antifungal activities against some strains of bacteria and fungi

Results: The result showed that the transitional metal compounds L2 and L3 exhibited sensitivities against Proteus Mirabilis while L3 exhibit sensitivities to Acinetobacter baumannii at highest dilution, however antimicrobial activities of the other derivatives against E. Coli showed no significant zone of inhibition. Among the 5 synthetic transitional metal compounds, L2 and L3 were found sensitive at concentrations 800 µg/ml. Transitional metal compound L3 showed a significant antifungal activity against Aspergillus flavus while no prominent antifungal activities were noted for the other derivatives. Other two strain of bacteria Candida albicans and Candida krusei were found resistant. Furthermore anticancer activity was carried out by using HepG2 and Vero cell lines respectively however nonsignificant cytotoxic activity of all five transitional metal compounds against the HepG2 and Vero cell lines. The cytotoxic effect were consider mild to moderate on both cell lines.

Conclusion: Overall, the tested transitional metal compounds exhibited selective antimicrobial activity but limited anticancer potential. Further structural modifications may enhance their biological efficacy.