THE ROLE OF NSAIDS AND METHOTREXATE IN MANAGING JIA

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Published: 2025-12-19
Keywords:
NSAIDS, Methotrexate, JIA, treatment, role

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Dr. Danish Ali
Dr. Ayesha
Dr. Afifa Ashraf
Dr. Amal Fahad
Dr. Hammad
Dr. Zainab Saeed Khan

Abstract

Methods: The study was a cross-sectional cohort study of 155 children with JIA who were 2-16 years old and who were evaluated using NSAID and methotrexate efficacy and safety measures using clinical, laboratory, and treatment-response variables. The data were gathered using standardized instruments and analyzed with SPSS with the significance value of p<0.05.


Results: In 155 JIA patients, MTX and combination therapy were more effective in ACR response, improving of the joints, and reduction of inflammatory markers compared to the NSAIDs. MTX had limited and minor adverse effects that were manageable whereas NSAIDs had minor gastrointestinal effects. The most successful outcomes were done through combination therapy.


Conclusion: Methotrexate remains the most effective long-term therapy for JIA, while NSAIDs provide short-term relief. Combination therapy offers added benefits, supporting a treat-to-target approach for optimal outcomes.

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Article Details

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Vol. 3 No. 12 (2025): The Research of Medical Science Review

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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

THE ROLE OF NSAIDS AND METHOTREXATE IN MANAGING JIA. (2025). The Research of Medical Science Review, 3(12), 442-448. https://medicalsciencereview.com/index.php/Journal/article/view/2754