IMPACT AND ASSOCIATION OF BREAST FEEDING WITH BONE AND LIVER METASTASIS IN DIFFERENT STAGES OF BREAST CANCER

Abstract

Aims: Goals of this study was to analyze the effect and correlation of breast-feeding practice upon breast cancer patients in the metastatic involvement of bones and liver.

Breast cancer is the most common cancer diagnosis in women globally and the second-leading cause of cancer-related death of women.

Research Design: Cross Sectional Study. (Observational Study)

Methodology: Study was carried out on 250 patients taken from Jinnah Post Graduate Medical Centre, (department of oncology) clinically and histopathologically diagnosed cases of breast cancer were selected for the study. Study design was approved by Board of Advance Studies, University of Karachi and ethical committee of Jinnah Post Graduate Medical Centre. TNM staging by IHC based on ASCO classification 2008 was done. For detection of liver and bone metastasis C.T scan bone scan and ultrasound was done.

Results: Frequency of breast cancer occurrence was found more in patients who did not breast fed their children. Significant correlation was noted between breast feeding practice and tendency to metastasize in bones and liver among all stages.

Conclusions: Breast feeding practice as appeared more protective tool from breast cancer development as well as it prevents metastasis to distant organs and slows progress of disease.