FREQUENCY & SPECTRUM OF GUILLAIN-BARRÉ SYNDROME IN CHILDREN PRESENTING WITH ACUTE FLACCID PARALYSIS

Abstract

Objectives: To determine the frequency of Guillain-Barré Syndrome in children presenting with acute flaccid paralysis and the spectrum of different types of Guillain-Barré Syndrome.  

Study Design: Descriptive cross-sectional study.

Place & Duration of Study: Three months w.e.f 10-02-2025 to 10-05-2025 at the Department of Pediatric Medicine, The Children Hospital and University of Child Health Sciences, Lahore.

Methodology: Children presenting with acute flaccid paralysis at the Pediatric Medicine OPD & Emergency Department of The Children Hospital, Lahore were enrolled after informed consent from guardians. Guillain-Barré Syndrome was assessed clinically using the Medical Research Council (MRC) scale and confirmed through nerve conduction studies for subtype classification. All patients received standard departmental management. Data were recorded by the resident and analyzed using SPSS version 27.0 for statistical evaluation.

Results: In this study, 98 children with acute flaccid paralysis were evaluated. The mean age was 9.67 ± 3.23 years, with male predominance (60.2%). GBS was identified in 36 (36.7%) cases, most commonly demyelinating subtype (63.9%). Although higher frequency was observed in younger children and males, no significant associations were found. 

Conclusion: Guillain-Barré Syndrome was identified as a significant cause of acute flaccid paralysis in children, with the demyelinating subtype being most common. Although higher frequencies were observed in younger age group and males, no statistically significant associations with age or gender were found. Early diagnosis and prompt management remain essential for better outcomes.