ASSESSMENT OF HORMONAL DYSREGULATION IN PATIENTS WITH POLY CYSTIC OVARIAN SYNDROME

Abstract

Background: Women of reproductive age are susceptible to PCOS, a common endocrine disorder marked by hyperparathyroidism, menstruation irregularoty, abnormal hormonal function, and disturbed metabolism. The clinical and biochemical manifestation of the syndrome is known to be

influenced by lifestyle factors and obesity.

Objective: To assess the relationship between body mass index (BMI), clinical characteristics, and lifestyle patterns and to measuure hormonal dysregulation in PCOS patients.

Methodology: A crosswise study involving 30 PCOS patients was carried out. Analyses of anthropometric measurements, structured clinical histories, and laboratory analyses of hormone parameters such as prolactin, testosterone, FSH, LH, T3, T4, and TSH were used to gather data. Participants were divided into groups with low BMIs (n = 10) and high BMIs (n = 20). Descriptive statistics, correlation analysis, and mean comparisons between groups were all included in the statistical analysis; p < 0.05 was deemed statistically valid.

Results: According to the study, 30% of participants were overweight, and 43% were obese, suggesting that PCOS patients have a high prevalence of elevated BMI. Acne, hirsutism, and hair loss were all common hyperandrogenic manifestations, affecting 40% of participants.In excess of 50% of the participants had irregular menstruation. Despite minor variations in hormonal parameters between groups with high and low BMI, none of them were statistically significant (p > 0.05). The connection was somewhat positive (r = 0.661) between the LH/FSH ratio and BMI,

indicating a possible link between gonadotropin imbalance and obesity.

Conclusion: The results show that substantial clinical and metabolic variability are linked to PCOS. Although obesity was common, this sample's basal hormone levels were not significantly impacted by BMI alone. Effective diagnosis and treatment require a thorough hormonal evaluation in addition to a lifestyle assessment. It is recommended that additional study be conducted using bigger sample sizes and metabolic markers in order to fully comprehend the connection between PCOS and obesity and hormonal dysregulation