COMPARATIVE STUDY OF INTRADERMAL TRANEXAMIC ACID INJECTIONS AND PRP THERAPY IN THE MANAGEMENT OF MELASMA

Abstract

Background: Melasma is a common pigmentary disorder characterized by brown to grayish patches that typically appear on the face. It most often affects women in their middle years and is more prevalent among individuals with darker skin tones.

Objective: To determine and compare the clinical effectiveness of intradermal Tranexamic Acid injections and PRP therapy in melisma.

Methodology: The study was designed as randomized controlled trial of the total of 40 patients clinically diagnosed with facial melasma will be enrolled in the study. The inclusion criteria of participants are that age between 20–50 years’ patients clinically diagnosed with facial melasma. The exclusion criteria of the participants are the pregnant or lactating women. patients with systemic illnesses. The self-structured questionnaire was use to compare the clinical effectiveness of intradermal Tranexamic Acid injections and PRP therapy in melasma.

Results: The participants (N=40). It shows that 35.0% of participants are 20–30 years old (14 people), 42.5% are 31–40 years old (17 people), and 22.5% are 41–50 years old (9 people). Overall, the largest group is the 31–40 year age range. There are two groups, and they are equal in size: TXA Injection includes 20 participants (50.0%) and PRP Therapy includes 20 participants (50.0%). Since both groups have the same number of participants, the treatment groups are well- balanced for comparison. The most common site is the cheeks, with 17 participants (42.5%). Full face is next, with 10 participants (25.0%). Forehead involves 9 participants (22.5%), while the upper lip has the fewest participants at 4 (10.0%). Overall, the frequencies sum to 40 (100.0%).

Conclusion: The study concludes that while PRP therapy may offer a slight edge in terms of the "glow" and speed of initial improvement, Intradermal Tranexamic Acid remains a highly accessible, cost-effective, and potent first-line injectable treatment. Often, the best clinical results are seen when these treatments are used as adjuncts to traditional topical therapies rather than as standalone replacements.