COMPARISON OF THE OUTCOME OF SINGLE-DOSE PREEMPTIVE INTRAVENOUS IBUPROFEN VERSUS PLACEBO IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY AT A TERTIARY CARE HOSPITAL, KARACHI

Abstract

Objective: To compare the hemodynamic and analgesic outcomes of single-dose preemptive intravenous ibuprofen versus placebo in patients undergoing laparoscopic cholecystectomy.Methodology:This randomized controlled trial was conducted at the Department of Anesthesia, Civil Hospital Karachi over six months. A total of 110 patients (ASA I–II, aged 40–80 years) undergoing elective laparoscopic cholecystectomy were enrolled and randomly allocated into two groups (n=55 each). Group A received intravenous ibuprofen (400 mg) 15 minutes prior to induction, while Group B received placebo (normal saline). Hemodynamic parameters (SBP, DBP, MAP, heart rate) were recorded at 30 minutes postoperatively. Pain was assessed using the Visual Analog Scale, and time to first analgesic requirement was noted. Data was analyzed using SPSS version 20.Results:Baseline characteristics were comparable between the groups (p>0.05). The ibuprofen group demonstrated significantly lower systolic blood pressure (122.6 ± 15.6 vs 130.8 ± 15.7 mmHg, p=0.007), diastolic blood pressure (74.5 ± 10.1 vs 83.4 ± 9.5 mmHg, p<0.001), mean arterial pressure (91.1 ± 9.5 vs 99.0 ± 9.0 mmHg, p<0.001), and heart rate (73.8 ± 10.6 vs 78.9 ± 11.8 beats/min, p=0.019). The mean time to first analgesic requirement was significantly prolonged in the ibuprofen group (594.7 ± 98.2 vs 228.4 ± 81.3 minutes, p<0.001), while rescue tramadol consumption was significantly reduced (59.1 ± 16.5 vs 85.9 ± 20.9 mg, p<0.001).Conclusion:Preemptive intravenous ibuprofen significantly improves postoperative analgesia and hemodynamic stability while reducing opioid requirements in patients undergoing laparoscopic cholecystectomy.