ALOE VERA AND HONEY ACCELERATING BURN WOUND TISSUE REPAIR: A COMPREHENSIVE REVIEW

Abstract

Burn injuries represent one of the most devastating and complex forms of traumatic tissue damage, affecting millions of individuals globally and imposing substantial burdens on healthcare systems. In order to care for burn wounds properly, we need a sort of multimodal plan that handles infection control, manages the inflammatory environment, and helps tissue regeneration along. Even though standard treatments— including silver sulfadiazine (SSD) and other topical antimicrobials—do work to a certain degree, they still come with notable problems, such as cytotoxic effects, the emergence of antimicrobial resistance, and slow or incomplete re-epithelialization Because of that, naturally occurring materials such as honey and Aloe vera (Aloe barbadense Miller) have really caught a lot of attention from researchers. They are being explored for several biological traits, including pro-tissue repair activity, microbial suppression, anti-inflammatory effects, and free-radical reducing potential. In general, the newest findings on how honey as well as aloe vera support faster and more synchronized healing of burn wounds are brought together in this review like discussion. When you look at aloe vera, its bioactive ingredients like acemannan, anthraquinones, vitamins, and enzymes work together to calm inflammation, enhance angiogenesis, encourage fibroblast expansion, and also assist keratinocyte movement. Honey s medicinal influence seems to come from hydrogen peroxide generation, methylglyoxal activity, defensin-1 peptides, an acidic pH, high osmolarity, plus a strong supply of phenolic antioxidant compounds.