A STUDY OF TRANFUSION TRANMISTTED INFECTIONS AMONG VARIOUS BLOOD DONORS TO ENHANCE SCREENING STRATAGIES FOR RISK REDUCTION

Abstract

The transmission of transfusion-transmissible infections (TTIs) is caused by the transmission of infected blood and blood components. The pre-transfusion screening of HBV, HCV, HIV-I/II, malaria, and syphilis is mandatory for blood component transfusion. Globally, HCV, HBV, and HIV are ranked first among the viral infections leading to mortality and also infect millions of people across the world, including dual and triple infections of HIV and HCV and HIV and HBV. The importance of the CFR’s contribution to ensuring blood safety cannot be overestimated, considering that the world experiences millions of blood donations every year. The primary aim of the study was to evaluate the effectiveness of blood screening protocols among healthy donors in reducing the risk of transfusion-transmitted infections (TTIs) .To assessed the prevalence of transfusion-transmitted infections among healthy blood donors and to identify the most common TTIs detected through blood screening among healthy donors.In Peshawar, Pakistan. Groups included total donors, in Lady Reading Hospital. The tests performed for HIV, HBV, and HCV were enzyme-linked immunsorbent assay, and for syphilis, rapid plasma reagin tests. The prevalence of HBV, HCV, HIV, and syphilis is presented in percentages. The comparison of the infection prevalence among the groups was performed using tests and P-values (<0.05). The study aims to assess the TTIs among a total of 250 blood donors in the peshawar region. The cumulative prevalence of overall TTI among the total blood donors The study aims to assess the TTIs among a total of 250 blood donors of peshawar region. The cumulative prevalence of overall TTI among the total blood donors was found to be 8.0%, and the specific ones for HBV, HCV, HIV, and vdrl were found to be 4.8%, 1.2%, 0.8%, and 1.2%, respectively. Ongoing strategies related to blood safety to each of the various donating groups and understanding the factors of the related socio-economic-health environment are important to improve blood safety.